Extreme Microfluidics: Large-volumes and Complex Fluids
Mehmet Toner PhD
Massachusetts General Hospital, Harvard Medical School, Harvard-MIT Health Sciences & Technology
Dr. Mehmet Toner is the Helen Andrus Benedict Professor of Biomedical Engineering at the Massachusetts General Hospital, Harvard Medical School, and Harvard-MIT Health Sciences and Technology. He serves as the Director of Research at the Shriners Hospitals for Children in Boston, and the Co-Director of the Center for Engineering in Medicine and Surgery. Dr. Toner received BS degree from Istanbul Technical University and MS degree from the Massachusetts Institute of Technology (MIT), both in Mechanical Engineering. Subsequently he completed his PhD degree in Medical Engineering at Harvard-MIT Division of Health Sciences and Technology in 1989. His research involves microfluidics, nano- and micro-technologies, tissue engineering and regenerative medicine, cryobiology. Dr. Toner is also co-founder of multiple biotechnology and medical device start-ups. Dr. Toner is inducted to the U.S. National Academy of Engineering, U.S. National Academy of Inventors, and the U.S. National Academy of Medicine.
Abstract
Microfluidics gained prominence with the application of microelectromechanical systems (MEMS) to biology in an attempt to benefit from the miniaturization of devices for handling of minute samples of fluids under precisely controlled conditions. Microfluidics exploits the differences between micro- and macro-scale flows, for example, the absence of turbulence, electro-osmotic flow, surface and interfacial effects, capillary forces in order to develop scaled-down biochemical analytical processes. The field also takes advantage of MEMS and silicon micromachining by integrating micro-sensors, micro-valves, and micro-pumps as well as physical, electrical, and optical detection schemes into microfluidics to develop the so-called “micro-total analysis systems (mTAS)” or “lab-on-a-chip” devices. However, the ability to process ‘real world-sized’ volumes efficiently has been a major challenge since the beginning of the field of microfluidics. This begs the question whether it is possible to take advantage of microfluidic precision without the limitation on throughput required for large-volume processing? The challenge is further compounded by the fact that physiological fluids are non-Newtonian, heterogeneous, and contain viscoelastic living cells that continuously responds to the smallest changes in their microenvironment. Our efforts towards moving the field of microfluidics to process large volumes of fluids was counterintuitive and not anticipated by the conventional wisdom at the inception of the field. We metaphorically called this “hooking garden hose to microfluidic chips.” We are motivated by a broad range of applications enabled by precise manipulation of extremely large volumes of complex fluids, especially those containing living cells or bioparticles. The use of high-throughput microfluidics to process large-volumes of complex fluids (e.g., whole blood, bone marrow, bronchoalveolar fluid) has found broad interest in both academia and industry due to its broad range of utility in medical applications.
Generative AI: How the world will evolve around it?
Burak Göktürk
General Manager and VP Engineering, Cloud AI & Industry Solutions, Google Cloud
As general manager and VP of engineering at Google Cloud AI and industry solutions, Burak oversees the teams creating products and solutions that empower every enterprise to transform their business with AI, including products that require little to no AI or machine learning expertise. This unique portfolio includes a unified platform to serve large models via Vertex AI, Unified Cloud Search, DocumentAI, and Conversational AI, along with industry solutions focused on healthcare, retail, media, and financial services
He also oversees development of ML technologies such as generative AI-based large language models and their application for real-world industry problems.
Burak has been in the AI/machine learning field for more than 25 years, published more than 40 papers, and holds more than 50 patents/patent applications. Burak received his MS and PhD degrees in electrical engineering from Stanford University and double BS degrees in electrical engineering and computer science from Boğaziçi University.
Abstract
Large models have recently advanced, and became readily available. Their ability to adapt to new tasks with no prior training, multimodal nature, and applicability to many use cases make them the biggest technology breakthrough of the last decade. In this talk, I will discuss key properties and short-comings of large models, and demonstrate various use cases. Finally, we will cover relevant issues, such as grounding large models with facts, multimodal models, and tuning them.
From Nano-Drones to Cars - A RISC-V Open Platform for Next-Generation Autonomous Vehicles
Luca Benini, Dr. Prof.
ETH Zürich and Università di Bologna
Luca Benini holds the chair of digital Circuits and systems at ETHZ and is Full Professor at the Universita di Bologna. He received a PhD from Stanford University. Dr. Benini’s research interests are in energy-efficient parallel computing systems, smart sensing micro-systems and machine learning hardware. He is a Fellow of the IEEE, of the ACM and a member of the Academia Europaea. He is the recipient of the 2016 IEEE CAS Mac Van Valkenburg award, the 2020 EDAA achievement Award, the 2020 ACM/IEEE A. Richard Newton Award and the 2023 IEEE CS E.J. McCluskey Award.
Abstract
The next generation of autonomous vehicles, with form factors ranging from tiny palm-sized drones to full-sized cars pushes signal processing and machine learning aggressively towards the edge, near sensors and actuators, with strong energy-efficiency, safety and security requirements, while at the same time raising the bar in terms of flexibility and performance. In the talk, I will describe our experience in leveraging the Open RISC-V ISA and open hardware approaches to innovate across the board and pave the way for an open embedded computing platform for autonomous vehicles.
Historical Peninsula
Hakkı Kaya Ocakaçan
Elected Member of the Board, Istanbul Branch, Electrical Engineers Chamber of Turkey
Born on October 1, 1955, in Istanbul, completed primary and secondary education in Istanbul. He graduated from Istanbul Technical University (ITU), Faculty of Electrical Engineering, Electronics and Communication Department in 1979. Completed his M. Sc. degree at the same university in 1982.
Started working as an engineer in the project group at Istanbul Water Administration in 1979 established the ISI Information Processing Service in 1980 and became the Information Processing Manager in that department. Started working as the General Coordinator at Bilser Computer Company in 1983 then as the Deputy General Manager at Grunberg A.Ş., a subsidiary of Profilo Holding, in 1985. He worked as a senior executive in this company, which produced and distributed AEG and SONY branded house hold products, until 1992.
In 1992, he became the General Manager at VESTEL AŞ and continued in that position until 1996.
Founded his own company specializing in consumer electronics in 1996.
In 2000, he taught retailing courses at Yeditepe University and participated in the establishment of the Logistics department at the university. He continued to teach in this department until 2004. Joined LCWAİKİKİ company as the Deputy General Manager in 2003 and worked as a senior executive until 2010. Started as the General Manager at RODİ AŞ in 2010 and continued in that position until 2014. Since 2010, he has been working as an independent consultant.
Tourism Background:
Passed the professional Tourism Guiding exam opened by the Ministry of Tourism in 1975 and started working as a tourist guide after completing the courses he attended for a year. Worked as a guide for a long time in companies such as CAMEL Tourism, DURU Tourism, TRANSBALKAN etc. Worked as a professional guide in all cities in Turkey and abroad. Studied at Istanbul University AUZEF History Department in 2013. Since 2015, he has been working as a staff guide and senior tourism consultant at VITRAY and DÜŞPATİKASI Tourism companies.
Currently serving as the Chairman of the Advisory Board of Istanbul Tourist Guides Chamber.
Historical Peninsula During both the Roman and Ottoman periods, the heart of the city was the Hippodrome, known as Atmeydanı by the Ottomans. The Hippodrome was located right next to the Bukoleon Palace, and the Emperor would pass through a gate and head to his box. The chariot racing clubs were like today''s political parties. In the year 534, the Rebellion of the crowds shouting "Nike" (victory) began at this point. The city was set ablaze and destroyed, and it ended with a massacre at this same location. It is said that Belisarius, the famous commander of Emperor Justinian, killed 40,000 rebels here, and the dead were buried in the Hippodrome.
Today, the famous Sultanahmet Mosque (Blue Mosque) stands in the place of the Imperial Palace next to the Hippodrome. Built by Sultan Ahmet I in 1617 and designed by architect Sedefkar Mehmet Ağa, this mosque, famous for its tiles, is a unique example of Ottoman architectural art.
Opposite the Sultanahmet Mosque, the Hagia Sophia stands with all its splendor. The magnificent structure we see today was built by the architects Anthemius of Tralles and Isidore of Miletus, under the order of Justinian, in place of the church that had burned down during the aforementioned Nike Rebellion. The church was opened for worship in 537. After the conquest of Istanbul by Fatih Sultan Mehmet, it was converted into a mosque and served as such until it was turned into a museum in 1934. It remained as a museum until 2020 when it was converted back into a mosque.
Right behind the Hagia Sophia stands another important Ottoman structure, the Topkapı Palace. The Ottoman palace, whose construction began seven years after the Ottomans'' conquest of the city, developed with new additions over the centuries. Reflecting the administrative center of the 600-year-old Empire, the Topkapı Palace is now a very important museum. The traces of both the Ottoman Palace Elite and the harem lifestyle can be clearly observed today.
The last structure I will mention in this area is the Archaeology Museum, which was built by Osman Hamdi Bey, the first museum curator in the Ottoman Empire, and designed by the famous architect Vaulary. The building is significant both as a precursor to early Turkish architecture and for the archaeological artifacts it houses. Among the important exhibits displayed here is the original copy of the Kadesh Agreement, the earliest written treaty in history.
During our tour, we will visit these monuments and provide information about their characteristics and historical background before the tour.
The final deadline for paper submission has been extended to July 15.
Special sessions are announced.
Selected papers from ICECS 2023 will be published in IEEE CAS Transactions II
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